Information about Jylamvo
What is it and what is it used for?
- active rheumatoid arthritis (a disease causing inflammation in joints) in adults;
- severe juvenile idiopathic arthritis (inflammation of joints in children) in patients from 3 years of age when NSAIDs (non-steroidal anti-inflammatory drugs) have not worked well enough;
- severe disabling psoriasis (a disease causing red, scaly patches on the skin) in adults when other treatments have not worked well enough;
- severe psoriatic arthritis (inflammation of joints that occurs in patients with psoriasis) in adults;
- acute lymphoblastic leukaemia (ALL), a cancer of white blood cells, in adults and children over the age of 3 years.
What are the benefits?
What are main side effects?
- breathing problems (these include a general feeling of illness, dry, irritating cough, shortness of breath, difficulty in breathing, chest pain or fever)
- spitting or coughing blood*
- serious peeling or blistering of the skin
- unusual bleeding (including vomiting blood), bruising or nose bleeds
- nausea, vomiting, abdominal discomfort or severe diarrhoea
- mouth ulcers
- black or tarry stools
- blood in the urine or stool
- small red spots on the skin
- fever, sore throat, flu-like symptoms
- yellow colouring of the skin (jaundice) or dark urine
- pain or difficulties in passing urine
- thirst and/or frequent urination
- seizures (convulsions)
- blurred or restricted vision
- severe fatigue
- loss of appetite, feeling sick (nausea), vomiting, abdominal pain, indigestion, inflammation and ulcers of the mouth and throat
- blood test showing raised liver enzymes.
- reduced blood cell formation with a decrease in white and/or red blood cells and/or platelets (leucocytopenia, anaemia, thrombocytopenia)
- headache, tiredness, light-headedness
- inflammation of the lungs (pneumonia) with dry cough, shortness of breath and fever
- skin rash, skin redness and itching
- lymphoma (lump in neck, groin or armpits with associated backache, weight loss or night sweats)
- severe allergic reactions
- dizziness, confusion, seizures
- lung damage
- ulcers and bleeding in the digestive tract
- liver diseases, reduced content of blood proteins
- nettle rash, skin reaction in strong light, brown discoloration of the skin, hair loss, increased number of rheumatic nodules, shingles, painful psoriasis, slow wound healing
- joint or muscle pain, osteoporosis (reduction in bone strength)
- kidney disease, inflammation or ulcers of the bladder (possibly also with blood in the urine), painful urination
- inflammation and ulcers of the vagina
- a blood disorder characterised by the appearance of very large red blood cells (megaloblastic anaemia)
- mood swings
- weakness in movements, also only limited to the left or right side of the body
- severe visual disorders
- inflammation of the heart sac, accumulation of fluid in the heart sac
- low blood pressure, blood clots
- tonsillitis, stopping breathing, asthma
- inflammation of the pancreas, inflammation of the digestive tract, bloody stools, inflamed gums,
- acute hepatitis (inflammation of the liver)
- discoloration of the nails,acne, red or purple spots due to bleeding from blood vessels
- worsening of psoriasis during treatment with UV therapy
- skin lesions resembling sunburn or dermatitis after radiotherapy
- bone fractures
- kidney failure, reduction or lack of urine production, abnormal levels of electrolytes in blood
- impaired sperm formation, menstrual disorders
- viral, fungal or bacterial systemic infections,
- serious disorder of bone marrow (anaemia), swollen glands
- lymphoproliferative disorders (excessive growth of white blood cells)
- pain, muscle weakness, changes in the sense of taste (metallic taste), inflammation of the membrane lining the brain resulting in paralysis or vomiting, pins and needles in arm and legs
- impaired movement of the muscles used for speech production, difficulty in speaking, impairment of language, feeling sleepy or tired, feeling confused, having unusual sensations in the head, brain swelling, ringing in ears
- red eyes, damage to the retina of the eye
- accumulation of fluid in the lung, lung infections
- vomiting blood, severe complications in the digestive tract
- liver failure
- fingernail infections, detachment of the nail from the nail bed, boils, widening of small blood vessels, damage to the blood vessels of the skin, allergic inflammation of blood vessels
- protein in the urine
- loss of sex drive, erection problems, vaginal discharge, infertility, enlargement of the breasts in men (gynaecomastia)
- pathological change of the white matter of the brain (leukoencephalopathy)
- bleeding from the lungs*
- bone damage in the jaw (secondary to excessive growth of white blood cells).
What studies have been done?
Reporting of suspected adverse reactions
Reporting suspected adverse reactions (side effects) after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals or patients are asked to report any suspected adverse reactions via the Yellow Card Scheme at yellowcard.mhra.gov.uk or search for MHRA Yellow Card in the Google Play or Apple App Store.
Disclaimer: This site is designed to offer information for general educational purposes only. The health information furnished on this site and the interactive responses are not intended to be professional advice and are not intended to replace personal consultation with a qualified physician, pharmacist, or other healthcare professional. We cannot provide individual medical advice. You must always seek the advice of a professional for questions related to a disease, disease symptoms, and appropriate therapeutic treatments.
For the full list of side effects and restrictions, see the package leaflet (link to package leaflet available in External Resources).