Browse Conditions Browse Medicines

Information about Melanoma

What is it?

This is a summary of information about this condition. For more detailed information we recommend using the NHS Choices website, A link to this can be found in the External Resources tab above.

Melanoma is a type of skin cancer that can spread to other organs in the body.

Superficial spreading melanoma
Around seven out of 10 (70%) of all melanomas in the UK are superficial spreading melanomas. They're more common in people with pale skin and freckles, and much less common in darker skinned people.

They initially tend to grow outwards rather than downwards, so don't pose a problem. However, if they grow downwards into the deeper layers of skin, they can spread to other parts of the body.

A GP should be consulted if patients have a mole that's getting bigger, particularly if it has an irregular edge.

Nodular melanoma
Nodular melanomas are a faster-developing type of melanoma that can quickly grow downwards into the deeper layers of skin if not removed.

Nodular melanomas usually appear as a changing lump on the skin which might be black to red in colour. They often grow on previously normal skin and most commonly occur on the head and neck, chest or back. Bleeding or oozing is a common symptom.

Lentigo maligna melanoma
Around one in 10 melanomas (10%) are lentigo maligna melanomas. They most commonly affect older people, particularly those who've spent a lot of time outdoors. They develop slowly over a number of years and appear in areas that are often exposed to the sun, such as the face.

To start with, lentigo maligna melanomas are flat and develop sideways in the surface layers of skin. They look like a freckle but they're usually larger, darker and stand out more than a normal freckle. They can gradually get bigger and may change shape. At a later stage, they may grow downwards into the deeper layers of skin and can form lumps (nodules).

Acral lentiginous melanoma 
Acral lentiginous melanomas are a rare type of melanoma that usually occur on the palms of the hands and soles of the feet. They can also sometimes develop around a nail, most commonly the thumbnail or big toenail.

Acral lentiginous melanomas are the most common type of melanoma in people with dark skin, but they can occur in people with any skin type.

Amelanotic melanoma
Amelanotic melanomas are also rare, accounting for about 5 in 100 melanomas (5%). They usually have little or no colour, but may occasionally be pink or red, or have light brown or grey edges.

What causes it?

Melanoma is caused by skin cells that begin to develop abnormally. Exposure to ultraviolet (UV) light from the sun is thought to cause most melanomas, but there's evidence to suggest that some may result from sunbed exposure.

The type of sun exposure that causes melanoma is sudden intense exposure – for example, while on holiday, which leads to sunburn.

Certain things can increase the chances of developing melanoma, such as having:
  • lots of moles or freckles
  • pale skin that burns easily
  • red or blonde hair
  • a close family member who's had melanoma

What are the symptoms and signs?

The most common sign of melanoma is the appearance of a new mole or a change in an existing mole. This can occur anywhere on the body, but the most commonly affected areas are the back in men and the legs in women. Melanomas are uncommon in areas which are protected from sun exposure, such as the buttocks and the scalp.

In most cases, melanomas have an irregular shape and are more than one colour. The mole may also be larger than normal and can sometimes be itchy or bleed. Look out for a mole which changes progressively in shape, size and/or colour.

What tests are used to diagnose it?

A GP should be consulted if any change to a moles. GPs will refer patients to a specialist clinic or hospital if they think the mole is a melanoma.

In most cases, a suspicious mole will be surgically removed and closely examined to see whether it's cancerous. This is known as a biopsy. A biopsy usually involves removing a small tissue sample. However, in cases of melanoma, the whole thing is usually removed from the beginning.

A test to check if melanoma has spread to the lymph glands (nodes) is often performed. This is known as a sentinel node biopsy.

What treatments are available?

The main treatment for melanoma is surgery, although treatment will depend on the circumstances.

If melanoma is diagnosed and treated at an early stage, surgery is usually successful.

If melanoma isn't diagnosed until an advanced stage, treatment is mainly used to slow the spread of the cancer and reduce symptoms. This usually involves medicines that target specific genetic changes in the melanoma, such as BRAF inhibitors, or medicines that boost the body's immune responses to the melanoma (so-called checkpoint therapies).

Once a melanoma has been diagnosed, there's a chance it may return. This risk is increased if the cancer was more advanced or widespread.

If the cancer team feels there's a significant risk of the melanoma returning, regular check-ups to monitor a patients health will be required. Patients are also taught how to examine their skin and lymph nodes to help detect melanoma if it returns.

Sources

NHS Choices website accessed on 29/09/17
Link to the NHS Choices website available in External Resources
Contains public sector information licensed under the Open Government Licence v3.0.

The medicines listed below have been approved for use in the UK. Medicines are listed by brand name and the active ingredient shown in brackets. An inverted black triangle (▼) against the name denotes that the medicine is being tracked for adverse events.

If the medicine you are interested in is not shown you can request it to be included by emailing the name of the medicine to medicinerequest@keepmeinformed.eu.

Medicines for this condition


Cotellic ▼ (cobimetanib)

Intron A (interferon alfa-2b)

Keytruda ▼ (pembrolizumab)

Mekinist ▼ (trametinib)

Opdivo ▼ (nivolumab)

Tafinlar (dabrafenib)

Yervoy (ipilimumab)

Imlygic ▼ (talimogene laherparepvec)

Braftovi ▼ (encorafenib)

Mektovi ▼ (binimetinib )

Disclaimer: This site is designed to offer information for general educational purposes only. The health information furnished on this site and the interactive responses are not intended to be professional advice and are not intended to replace personal consultation with a qualified physician, pharmacist, or other healthcare professional. We cannot provide individual medical advice. You must always seek the advice of a professional for questions related to a disease, disease symptoms, and appropriate therapeutic treatments.