Lemtrada (alemtuzumab) - patient safety update
Lemtrada, for Multiple sclerosis from Genzyme Therapeutics
- pulmonary haemorrhage, myocardial infarction, stroke, and arterial dissection within days of infusion – patients should seek urgent medical attention if they develop any symptoms of these disorders (see below), which may occur within a few days of treatment
- hepatic injury – patients should seek urgent medical help if they develop any symptoms of liver injury including abdominal pain, jaundice, dark urine, and unexplained nausea or vomiting
- haemophagocytic lymphohistiocytosis – patients should seek immediate medical attention if they develop unexplained fever, lymphadenopathy, bruising or rash, including if these symptoms occur several years after treatment
- patients should speak to their doctor if they have any questions about alemtuzumab for multiple sclerosis
- haemoptysis - the coughing of blood
- hypoxia - is a low amount of oxygen reaching the tissues of the body with resulting:
ataxia (poor balance and speech), confusion / disorientation / hallucinations / behavioral change, severe headaches / reduced level of consciousness, papilloedema (affects eye sight), breathlessness, pallor, tachycardia (fast heart rate)
- dyspnoea - difficulty breathing
- chest pain – the chest can feel like it's being pressed or squeezed by a heavy object, and pain can radiate from the chest to the jaw, neck, arms and back
- shortness of breath
- feeling weak and/or lightheaded
- overwhelming feeling of anxiety
- Face – the face may have dropped on 1 side, the person may not be able to smile, or their mouth or eye may have dropped.
- Arms – the person with suspected stroke may not be able to lift both arms and keep them there because of weakness or numbness in 1 arm.
- Speech – their speech may be slurred or garbled, or the person may not be able to talk at all despite appearing to be awake; they may also have problems understanding what you're saying to them.
- Time – it's time to dial 999 immediately if you see any of these signs or symptoms.
- muscle and joint pain
- a high temperature
- feeling and being sick
- feeling unusually tired all the time
- a general sense of feeling unwell
- loss of appetite
- tummy pain
- dark urine
- pale, grey-coloured poo
- itchy skin
- yellowing of the eyes and skin (jaundice)
- enlarged liver or spleen
- cytopenia (decreased number of blood cells)
- neurological abnormalities
Reporting of suspected adverse reactions
Reporting suspected adverse reactions (side effects) after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals or patients are asked to report any suspected adverse reactions via the Yellow Card Scheme at yellowcard.mhra.gov.uk or search for MHRA Yellow Card in the Google Play or Apple App Store.
Disclaimer: This site is designed to offer information for general educational purposes only. The health information furnished on this site and the interactive responses are not intended to be professional advice and are not intended to replace personal consultation with a qualified physician, pharmacist, or other healthcare professional. We cannot provide individual medical advice. You must always seek the advice of a professional for questions related to a disease, disease symptoms, and appropriate therapeutic treatments.
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