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Reagila▼ - approved for use in Scotland for the treatment of schizophrenia

Reagila▼, for Schizophrenia from Recordati Pharmaceuticals

The Scottish Medicines Consortium have approved the use of Recordati's schizophrenia treatment cariprazine, brand name Reagila▼, in adult patients.

This means that Reagila can be used and funded by NHS Scotland for use as a second-line therapy in schizophrenia patients where predominantly negative symptoms have been identified as an important feature.

In patients with stable schizophrenia with predominantly negative symptoms, cariprazine improved negative symptoms more than another second-generation antipsychotic.

You can follow developments on Reagila by using our Medicines Tracker service which provides users with updates about the medicines they are interested in.

About Reagila (source EMA)
Reagila is an antipsychotic medicine used to treat schizophrenia in adults. Schizophrenia is a mental illness with symptoms such as delusions, disorganised thinking and speech, suspiciousness and hallucinations (hearing or seeing things that are not there).

The active substance in Reagila, cariprazine, attaches to receptors (targets) in the brain for two neurotransmitters called dopamine and serotonin, which nerve cells use to communicate with neighbouring cells. Since dopamine and serotonin play a role in schizophrenia, by attaching to their receptors, cariprazine helps normalise the activity of the brain. This reduces symptoms of schizophrenia and prevents them from returning.

Reagila was first made available in the EU in 2017. It is manufactured by Recordati.

Sources
European Medicines Agency website page for Reagila
Accessed 15/05/19
Links available in full article

SMC information on Reagila

New medicines and vaccines that are under additional monitoring have an inverted black triangle symbol (▼) displayed in their package leaflet and summary of product characteristics, together with a short sentence explaining what the triangle means – it does not mean the medicine is unsafe. You should report all suspected adverse drug reactions (ADRs) for these products. ADRs can be reported by your doctor, pharmacist or online via the Yellow Card system.

Reporting of suspected adverse reactions

Reporting suspected adverse reactions (side effects) after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals or patients are asked to report any suspected adverse reactions via the Yellow Card Scheme at yellowcard.mhra.gov.uk or search for MHRA Yellow Card in the Google Play or Apple App Store.


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