Saturday 6th April 2019 | Source Manufacturer | Type EMA Marketing Authorisation decision
AstraZeneca have launched their treatment for hyperkalaemia (high levels of potassium in the blood). The medicine contains the ingredient sodium zirconium cyclosilicate (brand name Lokelma).
Lokelma captures potassium in the blood in exchange for hydrogen and sodium atoms. The exchange with potassium ions occurs throughout the gastrointestinal tract with onset in the upper part of the gastrointestinal tract. The trapped potassium ions are excreted from the body via the faeces, thereby reducing any excess and resolving hyperkalaemia.
Lokelma is licensed for the treatment of hyperkalaemia in adult patients.
Hyperkalaemia is the presence of an abnormally high concentration of potassium in the blood. Most data on
the occurrence of hyperkalaemia have been obtained from studies of hospitalised patients, and the number of patients with hyperkalaemia ranges from 1 to 10%. There is no agreed definition of hyperkalaemia, since the raised level of potassium at which a treatment should be initiated has not been established.
Hyperkalaemia develops when there is insufficient removal, excessive intake, or shift of potassium from the space between cells. Insufficient removal, which is the most common cause of hyperkalaemia, can be:
hormonal (as in aldosterone deficiency)
pharmacologic (e.g. treatment with angiotensin-converting enzyme inhibitors [ACEs]
angiotensin-receptor blockers [ARBs]
mineralocorticoid receptor antagonists)
most commonly, due to reduced kidney function.
Lokelma is a medicine used to treat hyperkalaemia (high levels of potassium in the blood) in adults. It contains the active substance sodium zirconium cyclosilicate.
The active substance in Lokelma, sodium zirconium cyclosilicate, is a potassium binder. When taken by mouth, Lokelma attaches to potassium from food and body fluids in the gut, forming a compound that is then eliminated in the stools. This action removes potassium from the body overall, thus helping to lower the potassium levels in the blood.
Lokelma was first made available in the EU in 2018. It is manufactured by AstraZeneca.
European Medicines Agency website page for Lokelma
Merck Manual website for hyperkalaemia
Contains public sector information licensed under the Open Government Licence v3.0.
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