NICE recommend tildrakizumab (Ilumetri▼) for the treatment of moderate to severe plaque psoriasis
Ilumetri▼, for Nummular psoriasis and Psoriasis
Wednesday 24th April 2019 | Source NICE | Type NICE decision
The National Institute for Health and Care Excellence (NICE) has approved Almirall's psoriasis treatment tildrakizumab, brand name Ilumetri ▼ for use by the NHS in England and Wales.
The full recommendation states that:
Tildrakizumab (Ilumetri) is available on the NHS as a possible treatment for plaque psoriasis in adults if:
the psoriasis is severe and affects quality of life and
the psoriasis has not improved with other treatments, for example, ciclosporin, methotrexate and phototherapy, or these can’t be taken.
Tildrakizumab may be stopped between 12 and 28 weeks of starting treatment, but should be stopped at 28 weeks if the psoriasis does not improve enough.
When assessing how psoriasis affects your quality of life, healthcare professionals should take into account any disabilities or difficulties in communicating you might have.
If you are not eligible for tildrakizumab but are already taking it, you should be able to continue until you and your doctor decide when best to stop.
You can follow developments with this medicine using our Medicines Tracker service which provides users with updates about the medicines they are interested in, including updates to Patient Leaflets, information from medicine regulators and clinical trial information. To track information about this medicine please click on this article and follow the 'About this medicine' link then select 'Follow medicine'.
Psoriasis treatment pathway. NICE
Ilumetri is a medicine that acts on the immune system and is used to treat plaque psoriasis, a disease causing red, scaly patches on the skin. It is used in adults with moderate to severe disease for whom treatments applied to the skin are not suitable.
The active substance in Ilumetri, tildrakizumab, is a monoclonal antibody (a type of protein) which is designed to attach to interleukin 23 and block its activity. Interleukin 23 is a substance that controls the growth and maturation of some types of T cells. These T cells, which are part of the immune system (the body's natural defences), are involved in causing inflammation that is linked to the development of plaque psoriasis. By blocking the action of interleukin 23, Ilumetri reduces inflammation and symptoms associated with the disease.
Ilumetri was first made available in the EU in 2018. It is manufactured by Almirall.
European Medicines Agency website page for Ilumetri
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